- Title
- Dietary protein affects both the dose and pattern of insulin delivery required to achieve postprandial euglycaemia in Type 1 diabetes: a randomized trial
- Creator
- Evans, M.; Smart, C. E. M.; Paramalingam, N.; Smith, G. J.; Jones, T. W.; King, B. R.; Davis, E. A.
- Relation
- Diabetic Medicine : A Journal of the British Diabetic Association Vol. 36, Issue 4, p. 499-504
- Publisher Link
- http://dx.doi.org/10.1111/dme.13875
- Publisher
- Wiley-Blackwell
- Resource Type
- journal article
- Date
- 2019
- Description
- Aim: To quantify the insulin requirement for a high‐protein meal compared with a low‐protein meal, controlling for carbohydrate and fat content. Methods: In this crossover study, young people with Type 1 diabetes were randomized to consume a high‐ (60 g) or low‐protein meal (5 g), each containing 30 g carbohydrate and 8 g fat. A variation of the insulin clamp technique was used to determine the insulin requirements to maintain euglycaemia for the following 5 h. Results: A total of 11 participants (mean ± sd age 16.5 ± 2.7 years, HbA1c 52 ± 8.7 mmol/mol [6.9 ± 0.8%], diabetes duration 6.9±5.1 years) completed the study. The mean insulin requirements for the high‐protein meal were higher than for the low‐protein meal [10.3 (CI 8.2, 12.57) vs 6.7 units (CI 4.7, 8.8); P =0.001], with inter‐individual requirements ranging from 0.9 to six times the low‐protein meal requirement. Approximately half the additional insulin [1.1 units/h (CI 0.5, 1.8; P =0.001)] was given in the first 2 h, compared with an additional 0.5 units/h (CI –0.2, 1.2; P =0.148) in the second 2 h and 0.1 units (CI –0.6, 0.8; P =0.769) in the final hour. Conclusions: A high‐protein meal requires ~50% more insulin to maintain euglycaemia than a low‐protein meal that contains the same quantity of carbohydrate. The majority is required within the first 2 h. Inter‐individual differences exist in insulin requirements for dietary protein.
- Subject
- Type 1 diabetes; protein; carbohydrate; insulin requirements; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1459041
- Identifier
- uon:45562
- Identifier
- ISSN:0742-3071
- Language
- eng
- Reviewed
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